To abandon a friend (in most cases, best friend) within their presence in order to hang out or become best friends with another.

It is also used to address to someone who has "flew off".
Guy 1 - "Your flying off on me?!"
Guy 2 - "No it's not what it looks like, we're just talking to each other!"

Guy 1 (a week later) - "Hey there fly off! How's your new friend?"
Guy 2 - "Screw you"
by Johnthebapteest September 17, 2010
Get the Fly off mug.
To become angry or enraged.
"I'm Buddy Rich when I fly off the handle!"
by Socko August 10, 2004
Get the fly off the handle mug.
to become infuriated, to lose all control of your actions
"Don't f*** with me right now, or I'll fly off the chain."
by .K+. January 10, 2009
Get the fly off the chain mug.
When a lowlife person or group entity of people abandons one particular foul interest or behavior for one even worse, such as flies would abandon a mere pile of shit for a foul-smelling, bloated and rotted carcass.
"All of today's Republicans adore Donald Trump and want to become more and more like him every day, so they sure as hell ain't gonna be flying off the shitpile just for a moderate conservative like you!"
by red phillips May 14, 2020
Get the Flying off the shitpile mug.
when you really just yeet on the enemy team in black ops 4
David (before playing black ops): Guys, I'm bout to fly off the fucking rails.

David (while playing black ops): I'm flying off the rails!
by yeetusmaximus9000 October 24, 2018
Get the flying off the rails mug.
An insult to someone's intelligence or ability, or describing an individual who is struggling to keep up with the rest of the pack
. A 'cold shot' refers to a steam-catapult launch from an aircraft carrier when the steam pressure is too low for the launch weight of the aircraft; on reaching the end of the deck, the aircraft is going too slowly for safe flight and may drop dramatically, or even (in extreme cases) ditch. If ditching is avoided, there follows an agonisingly slow climb away with the handle jammed forward and all the gauges pegged in a desperate attempt to gain height and speed.
"So what's the new guy like, any good ?"
"Man, he's flying off a cold shot."

"How's the training going ?"
"I feel like I'm flying off a cold shot"
by Eighth of Seven January 7, 2007
Get the Flying off a cold shot mug.
When one gay male wants to have his Anus stimulated by another male.
by the badass of all badass. September 26, 2016
Get the Flying suck off my ass mug.