The term "homeboy" derrives from "homie", and each of those terms have been shortened down overtime as "homes", or sometimes spelled "holmes". The term was started by Mexican-Americans living in the barrios of Los Angeles, most commonly said in East Los Angeles. The term refers to friends/companions living in the same neigborhood as eachother. Which is why "HOME" is started before boy, thus creating "homeboy".
Person 1: Aye whats happening homeboy?
Person 2: nothing just chilling, you?
Person 1: about to go to Rob's house...
Person 2: who that? is he a homeboy?
Person 1: Nah... just some foo i kick it with from Grape Street.
by Eddie.P March 24, 2007
Get the homeboy mug.
Homeboy like "Homie" is an English language slang term found in Westcoast American urban culture, whose origins etymologists generally trace to Mexican-American Spanglish from the late 19th century, meaning a male friend from back home, close friend, or someone gang affliated.
This my Homeboy from Los Angeles.
by Andre Santana January 2, 2018
Get the Homeboy mug.
When this term originally began to proliferate in the 1970's it was a derogatory term for someone in the neighborhood who 'stayed inside the house"- had little experience, was afraid to take chances, wasn't cool, kinda sissified; a cat who stayed home with his momma.
Let's go to the store an' git some Now Or Laters...

Naw, I can't. Moms won't lemme ride my bike in the street.

Youse a real homeboy.
by lionstanding November 3, 2011
Get the homeboy mug.
The epitome of a friend. Somebody you kick it with. A person who always has your back. You can't go through life without a homeboy. It's hard to have more than one, because they're one in a million.
You ain't nothing without your homeboy. - Tupac Shakur
by Kalseng December 21, 2010
Get the Homeboy mug.
a term used commonly in hoods and ghettos closely related to Dawg. the elongated version of homeboy.
for those who have more time for greetings, "Homeboy" can be replaced by something like "Home skillet biscuit on a sesame seed bun with creame cheese mustard jello and ketchup on a sunday morning" Homeboy is often associated with "sup" and "yo."
Yo, sup my homeboy baked fresh on a homeskillet homebiscuit homemade by my momma?
by i am not black May 26, 2005
Get the homeboy mug.
HoMeBoY(Z)_Pl.

Cats I'm tight with, chill wit, puff with, roll with, got Love for.
P-CP, Chris M, Chris O, Jav, and J are my HoMeboYz.
by LaLa January 6, 2004
Get the homeboy mug.
A slang word for friend, family. Gangsters and raper's will use this word.
'' Yo homeboy, Drop by the club, smoke some shit ''
by Mariokev June 20, 2009
Get the Homeboy mug.